I say yes! have been seen after using medications in this class of drugs. He also lashes at me with his teeth. At the same time, it opens glutamate-gated channels, which adds to the flood of nerve communications. He seems back to his normal self and playing with his toys, but we will not continue the following doses! I gave my six-year-old dog SIM perica because the combo guard was on back order. I am so mad at myself, he was on Heartguard + nexgard for most of his life and the vet recommended we try Simperica Trio. Yep days ago started vomiting and having seizures. My precious rescue has been sick twice, currently on her second episode. About 2 weeks later he had tremors, drooling, lethargic, uncoordinated, vomiting and was touch and go for a couple days. She text me asking if she ever had seizures before. The FDA considers this level to be "very rare". Hoping you are the lucky ones!! I just cross my fingers every day that she will get better after this is out of her system. I called the manufacturer (Zoetis) and filed a report, immediately discontinued the tablets and started to detox him. I am a new dog owner, gave my 14 weeks old german shepherd the 1st Simparica trio pill yesterday morning 8 am, she starts to vomit around 5 pm, having more frequent uranating, and loose poop, this continued until 8 pm when she's tired and finally slept. Moxidectin stops heartworm . He has been low energy since. Those incidents are still under investigation because the numbers of report are extremely low. Thannks !! I lost my dog due to Simparica Trio. Its been 10 days since I have my dog this drug and they are now telling me he has meningitis. Before sharing sensitive information, make sure you're on a federal government site. So now after $90.00 spent on three pills this month, I decide to look up the answers myself. Ours lasted about a week. If fact it specifically states on the product label "Not for use in humans". I fed him a diet of boiled chicken and rice for 3 days and began to introduce his food which is a limited ingredient type. Would you mind sharing what happened with your pup? I have her home, but she has been at the Emergency Vet last night, and her normal vet all day. By Sunday he is having liquid diarrhea! I would forego either unless you really have a serious flea issue that can't be solved with a flea collar. However, since the seizure a month ago he suddenly had another one when we tried to sleep in another bedroom while painting our bedroom ( where he slept with us). I know Dukes problems were from this medicine, and it upsets me that my vet told me that this medicine was safe! Very small sample - many deformities, stillborn. Vet said if she vomits bring her in. I sure hope he makes it! like she wants me to fix it. I will never give this again! Couple of days ago, I took my other doxie (Maddie) into my vet, for shots, he did the heart worm test and recommended Simparica. Then they come back! the first puppy was still born looks to have died younger .my assumption when I gave lola that pill.she lost 1 puppy .the second baby is doing okay.although the vet said watch for neurological problems and GI problems. Although the price may be even lower via online pharmacies, Zoetis only guarantees the product when purchased directly though your vet (in the clinic or via their online pharmacy). I am very worried I called the vet they said oops sorry they made a mistake. I have my 10mth old Iggy her first dose and since having this brand she has been shaking for the last 10 days we have been to the vet she has had IV fluids to push the drug out of her system and has had valium but all with minimal affect!!! How is your puppy now after 7 months leases our 2 yr old frenchie just spent 3 days hospitalized and clearly has neurological symptoms. No more of this junk for my pups! He had never pooped in the house and now he does every time he has to be put in his indoor pen for us to leave or sleep. Let us now look at possible side effects when administering Simparica. Had I of done my research before hand, I never would have giving it to him in the first place. Ekko then started having seizures in May,June and July. I am keeping a close eye on her and will take her to the vet if she hasnt improved by tonight. 24 hours after, we noticed diarrhea. It causes paralysis that leads to death of hookworms and roundworms. Contrary to the statement in that same above article "The results are fatal for fleas and ticks but safe for mammals such as your dog." I left a lot out but didnt want to make too lengthy post. Well, let me tell you: THANK YOU ALL FROM THE BOTTOM OF MY HEART. My dog (6 years old) has been using monthly Simparica since I got him. Hes very lethargic and constant vomiting! So scary. Monday, Tuesday, Wednesday and Thursday he slept all day, was hesitant to get up, wouldn't play with his ball, continued to drink excessively and shivered. Stopped meds and he has had 3 more seizures since. She's finally resting at home, but still not able to walk, run, eat, etc. Can blocking GABA receptors also cause inflammation of spine? All they care about is the money and not the animal. Vet trip and meds $400! My dog was HEALTHY and HAPPY prior to giving him this drug and literally days later he is struggling to recover. I thought it was just her aging but now I think it al started when she started this medication. Are their enough people to file a class action suit? I called the vets office and they informed me that this medicine only had vomiting and diarrhea as side effects. No way I will ever give it to her again. Not known if there be permanent after-effects. He has no appetite. Nothing they can do for her she said. The active ingredient of Simparica, sarolaner, belongs to a newer class of flea and tick preventatives called isoxazolines. Then she started having tremors. The third ingredient in Simparica Trio is pyrantel. You ask why they are giving this poison to our furbabies, it's easy. After reading theses comments I started looking into SIMPARICA TRIO. I pray for my baby to be ok and all of you who are in this battle. He seems dehydrated. My dog has had 3 seizures in the past from wearing a flea collar. Needless to say, we will no longer be giving this to our lab or our other dog. Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs Revolution Plus (selamectin and sarolaner) topical solution for cats These products are approved for the treatment and. I hope it has no permanent impact on him. I gave my yellow Lab, Sophie, her first Simperica trio. I gave my dog simparica at 10:15am. I am sure simparica caused a fatal seizure in my boxer. Come to find out Akita blood platelets can explode in storage causing hi readings. In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. Bravecto has six topical solutions for dogs by weight/size. If it has been a long period of time since the last dose was given, you may see fleas temporarily during the missed time. I'll be spreading the word. Barely eats, but is drinking lots of water. Vet prescribed this for my 12 week old border collie Lab mix. Gave this to my dogs and now he sleeps all the time and tired and has symptoms now like droopy right side weakness cant blink right eye and drooling like bells palsy. But then the first time I increased from 6mg to 12mg (again on advice of the vet) as his weight increased, the tremors got noticably worse and he started stumbling for no reason. Will be back at PetSmart on Monday. It has been 5 days since she had the 3 seizures in 24 hours. The next day she had diarrhea. Copyright 2023 Meredith Corporation. We have a 3 month old Aussie labradoodle and the breeder warned against oral flea meds. (Ours never did, she died 4 months later.) It's not worth the risk of additional seizures or other neurological effects, and it seems that his stumbling and getting tired sooner on walks are likely related. After second pill, weve notice he has been a bit down for a couple days. Sold as 1 Month, 3 Month or 6 Month Supply for the following dog weights : 2.8-5.5 lbs, 5.5-11 lbs, 11-22 lbs, 22-44 lbs, 44-88 lbs, 88-132 lbs. Next she developed severe tremors. My shepherd got it the following month and I called the vet again and she prescribed probiaotics and anti diarrhea meds again. 100% effective, zero side effects. I notified my vet and Zoetis, the company that makes this drug. old . They may not be ready to beat you in a game of chess, but these brainy dogs are easy to train and generally eager to please you. Today the seizure like attack happened even though he is on the steroids. After seeing his condition worsen, that night we took him to an after hours urgent care. Coincidence? Additionally, many tick-borne diseases can affect humans as well as pets. How can they put something that can cause this level of damage on the market and how do vets not even tell us to monitor our pets or tell us what the risks are. corgi lying in grass next to woman's feet. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. I will be discontinuing the medication. He had full wellness exam three ago and was in perfect shape. This went on for 4 hours. Hello! Was not too excited about it, and I really should've declined it. The next day Bellas stools were quite soft but still had some structure. He's experiencing auto-inmune disease symptoms and we were told he is in critical condition. Also - do NOT use Bravecto for females you intend to breed. She has what is called knuckling. They want another blood draw in 3 weeks to see where she is. Today shes been panting. Seizures continue and its Monday. 3 months ago he began having seizures, he had one every day for a week. Giving our sweet dog Simparica was the biggest mistake we have ever made as far as our pets. Possible Side Effects. Would appreciate any opinion you all may have. She walks around as if she is on ice with no control of her back legs. He has been very lethargic and usually super active, jumping and chasing balls. I gave this to my 8 yr old chihuahua and a couple days later he started having seizures. Head down, tail down, will stand in a corner and stare at the wall. He protected our livestock from coyotes for many years and I took good care of him. Is it just me or does it seem like everyone is in this together? its only been about 4 days since and its been a steady decline. I gave my almost 10 year old chihuahua mix (11lbs) his first dose on Wednesday and he has started coughing and sputtering since Thursday nite. Animal Drug Safety Communication: FDA Alerts Pet Owners and Veterinarians About Potential for Neurologic Adverse Events Associated with Certain Flea and Tick Products, How to Report Problems with Flea and Tick Products, An official website of the United States government, : I will have to keep an eye out on her. Simparica Trio can be administered to your dog at any age, but it's best to start treating your dog one month before the fleas become active. I just wanted them gone and for him to feel better. Did you go to the vets or not? According to the FDA, Simparica Trio contains the following active ingredients: "Sarolaner was first approved by the FDA in 2016 to treat and control flea and tick infestations. I took her home. One nite she ended up in emergency pet hospital they drained 1/2 liter of fluid off her and did lots of tests., wanted to put her "DOWN" With what she went thru tht day we didn't want tht to be her last day. GAGA-gated channels help to calm nerve transmissions, which sarolaner alters, creating an influx of nerve transmissions. Please advise! Thankfully I have had experience with dealing with this with my kids and relatives so I dosed him with Benadryl. I did some research and because he seemed otherwise fine, I assumed it was "small white dog" shaking due to his breed mix. 1 is pregnant I told the vet what can I give the pregnant yorkie she said sampirica sold me a 3 month supple for her. My American Akita puppy took this pill on August 8th. Side effects include: vomiting, diarrhea, lethargy, anorexia, otitis externa (ear. Compared to other products, the efficiency of this . What are the side effects of Simparica trio for dogs? We may also give additional medications to keep fleas, ticks, and common intestinal parasites away. His first was a week after taking his simparica. In the meantime i keep trying to give him ice and i am very worried that i have permanently harmed him. I hate giving her these drugs in the first place but am always convinced it is the right thing to do. He just isnt himself. I honestly think she had a reaction to the medication. Somedays he will have 2 and then he will go for a couple days without having any issues. We were told the Neurologist would be between $10,000 to $12,000. On Friday he was incredibly thirsty - he would drink a full bowl of water and then look at me for more. Is your dog still having tremors? If my dog dies, which does not look too good right now for him, I will stop at nothing to make the company's life miserable. The vet has not been able to diagnose a cause. Next day, he was suddenly 1000% worse, would not touch food, could not move. Vets at Petsmart should know better; changing vets. He was a Shih Tzu. In isolated cases, however, dogs displayed more serious reactions such as tremors, muscle twitching, and seizures. He does well on Simparica trio and also has the Lyme shot ? Because this ingredient works differently on invertebrates than mammals, however, Simparica for dogs has been proven safe during field trials. I'm hoping the tremors will soon diminish, since she is in great shape otherwise. I took him to the energy vet in the morning, he couldnt find any cause for pain, only he yelped a bit on his neck, they had trouble getting him in, he was yanking his neck around as he is afraid of the vet since getting fixed. I too would like to know how long this symptom lasted in other dogs who experienced the same issue. Work up from the neurologist shows all his tests came back negative. Sorry to hear about this happening to so many. he didn't throw up but he doesn't want to go to bed at night and he just paces around the bedroom and sometimes goes under the bed. I'm so sorry. My Miles is having this SAME issues, started Simparico Trio in May and he got his second does June 1, by June 5th he wont eat, walk and or bark! Simparica, Nexgard, Bravecto and Credelio are part of a group called Isoxazoline drugs. AVOID THIS PILL! I wish I would have seen this site before I gave it my Matty. At the same time, it opens glutamate-gated channels, which adds to the flood of nerve communications." She had the tablet on the Thursday and by Friday she had two very servere seizures, she is nearly three and never seen a vet before only for vaccines. . After about 2.5 weeks, she couldn't walk, bark, had tremors, didn't want to eat, and was so lethargic I thought we were going to lose her. I feel like it was a massive overdose. My sincere sympathies to those with horrendous seizure side effects. Im certain that its the simparica. It is important to work with your veterinarian to ensure the best flea/tick and heartworm prevention plan for your pets specific needs. She became very neurotic, so many changes in her personality and she became very anxious her first and only dose was in November 2020 she never returned to the special dog that we had and she passed in March 2021 at 8 years old. That evening after giving it to him he has puked various times. I am currently in the same situation and we are at day 16 after giving simparica. Dogs with existing heartworm infections should be treated to remove the adult heartworms before going back on this medication. He is pissing a lot and often and drinking a lot of water. Again he has diarrhea and this month he seems agitated or nervous. The cost of Simparica Trio generally ranges from $2230 per dose depending on the tablet size, number of doses, and source of purchase. This is apparently not true and that's why the article never goes on to explain exactly why it only works on GABA receptors in fleas and ticks yet not affect the GABA receptors in your dog. Then I gave it to her again the 3rd month and the same thing happened. I gave this to my 4 month old puppy and was not told of the neurological side effects. Mine was given the medication 9 days ago. We have spent well over $5000.00 and upset about all the horror stories we are now hearing. I will not be giving this medication again! My beautiful boxer lost his appetite after just one dose of Simparica. Pyrantel pamoate is a nematocide (kills some worms) belonging to the tetrahydropyrimidine class. He also got that odd cough here and there that I read someone else mention. I am so sorry to all of you and my heart goes out to you and your babies. I took my dog to the vet today and she received fluids and gabapentin. I fell like hes dying right before my hands. The vet just gave our 16lb shorkie this on Tuesday and he still has the tremors really bad and very lethargic, Im very worried and concerned. No more Simparica for him. They gave him IV glucose to raise his Potassium level. They drew blood & took a fecal sample . He is back to his old self now but we will never give him this medication again. 3 days later, one of the dogs had severe vomiting for a day, then turned into severe golden diaherria going on a week now! Meaning he is suppose to get it today. I would NEVER recommend this medication. I am interested in the petition and the company's response. No more simparica for her or my other 2 dogs who each still had a dose of comfortis. I gave my black lab mix Simparica for the 1st time on 4/1. He slowly recovered over 3 weeks until he is just now starting to return to normal activity level. The vet has reported it (at least she too thinks it came from the drug) and a chiropractor checked her for the possiblility of slipped disc etc and said it's not that. Its a horrible product and our puppy experienced a horrible reaction that eventually in a very short time took a young vibrant active very intelligent pups life in a horrible way - our Frazier would have turned 8 this past Memorial Day and we miss him everyday, I should have clarified Frazier was walking in circles because the siezures blinded him - our other puppy Watson has since only used next guard and heart guard without any further incidents but along with us showed signs of compassion during Fraziers last days and grief towards the loss of his brother Frazier. They are monitoring her. Revolution has been around decades with less incidents of animal reactions. I am so mad at myself for letting the vet talk me into this. They were ok on that but the vet office is no longer going to carry regular Simperica so we took the Simperica trio that is now in its place. Never again are my dogs getting oral medication for fleas & ticks. If she comes out of this I will return to heartworm pills and topical flea and tick meds. Why the vets use this treatment after so many side effects being reported is disgusting. It is recommended to wash your hands after administering this medication. Hopefully having gotten your pup off it right away will make your outcome better. Hi, we did a spinal tap and MRI, its not viral or bacterial, its called steroid responsive meningitis which essentially is the meninges inflaming on their own, but if you look in this thread youll see others reporting similar symptoms/diagnosis so I do think Simparica trio triggered/caused it. We took him to vet and they gave nausea meds and kept him overnight. so what about her puppies I am so worried. I sure hope we don't have ongoing problems. Heartworm medicine alone should be ok. Oh my god I'm so glad I found this group. Supposedly it is MDR1 friendly but side effects include ataxia which is what my girl got. This is lethal medication for dogs and should be taken off the market now. I have a person that bought a husky puppy from me March 6 @ 6 weeks old. Now tremors started. I even said "I am reading a blog, right now, with pages of stories about this drug and the side effects". Chris, there is hope, for me, after about 35 days from when I gave my dog simparica trio all side affects went away, his blood levels where normal and no longer pies and drinks water non stop. I recently switched my 3.5 year old German Shepard to simparica and about 2 weeks after his first dose he had two seizures in one night and has NEVER had them before. These are the side effects that were observed: Most common is vomitting Weakness and lethargy Soft stools Loss of appetite Snores like a big dog. now almost exactly two months later, sick again with a fever and stops eating. Thank you for giving information on what happened to your dog. Was hospitalized for 2 1/2 days. Please do NOT use it!! This spring I gave her one dose, and the tremors soon were back and much worse. Simparicaworks by impacting the nervous system of invertebrates such as fleas and ticks. Other adverse reactions like lethargy, anorexia, itching, and increased thirst are possible but not very likely. And then when we finally stop for the evening - she crashes. He also would have crying spells while trying to sleep but showed no signs of pain. He is 5 months old. But I have decided not to give the replacement pill today. Two quick questionsDo the dogs eventually return to normal? Customer: Took a dose of simparica trio.second rose in second month.dog is having tremors JA: I'll do all I can to help. I'm so sorry. I immediately filed a case number with Zoetis and informed my Vet as well as current Vet hospital he is being held at. I've beaten myself up so much giving her this drug, I felt I could trust the vet and the drug company but we obviously cant and it's all about making more money. Called Vet tonight and got a first appointment for tomorrow morning . I would advise against the drug based on my experience so far, it can get worse and the reviews that I have read online about the product. Reading all these similar cases cant figure out how the hell this crap is still being prescribed. Side effects are uncommon, but may occur in some cases. I'm so glad I found this forum, it confirmed my instincts that this drug is very harmful. He is acting very skittish/scared like behavior, wants to just lay down. If anyone has discovered what can help please let me know. She had a marked alteration in balance, lost her ability to navigate stairs, and lost all vocalization for almost 4 weeks. He also had a seizure that lasted for about 2 minutes in the middle of the night about 2 months ago and it was the most horrifying thing to watch and feel so helpless. He has been resting most of the day so far, thankfully no seizures.. but I promise I will not be giving him the other 2 doses I got from the vet after reading all of the experiences everyone else has had with their animals. At vet visit - vet noted redness in the eyelids but thinks it may be caused from the wind? but wasnt allowed in with him. Hi, I was just wondering how long you continued on with the steroids with your puppy. Does your do still have a cough? He hasn't eaten since and grazes on grass like he is a goat. My dog is having the same issues. He was a normal dog before the medicine Simpatico Trio . This should be taken off the market-it's just a BIG pharmaceutical moneymaker at the expense of animals and their unsuspecting owners. My vet gave us Simparica for my newly adopted Chihuahua yesterday. It's unique because it kills more types of parasites than any other combination product available to date. So no Addisions. It works by creating uncontrolled neuromuscular activity leading to death in fleas as well as some ticks and mites. Simparica can't be used on younger dogs or lactating dogs whereas Revolution can. Monday morning - 11 days after he is like a zombie - all motions are almost mechanical and when I talk to him it takes him a long while to react. A month later, he was at doggie daycare and we picked him up and he was panting frantically. He is 11 so I attributed his slowing down on walks to aging but now he is recently limping and at times has some trouble with jumping up on the bed. Needless, to say I will not be giving them the simparica trio again. As of today, Sadie's ability to eventually meet the strict certification requirements in that pursuit, remains guarded, although her progress prior to this event had been stellar. Were there any other conditions? Been also very lethargic not wanting to get out of bed. How is your cockapoo doing now? Buddy 8 year old male Boxer formerly energetic and playful. Although the mother that took the same had not shown any effects. Vet gave her a shot which stopped it. It is really eye-opening to see everyone's experiences. Once again peed in my office on Saturday. Zoetis claims it will be out of his system in two months and I should not see lasting effects, so I am hopeful but worried and telling everyone I know NOT to use this poison. The next day, he was panting frantically % worse, would touch! Until he is struggling to recover to my 4 month old puppy and was touch and go for a days. How long you continued on with the steroids with your pup off it right will. Was not told of the neurological side effects have 2 and then he will have 2 and he... And he has been proven safe during field trials reaction to the tetrahydropyrimidine class this will! No signs of pain this group twice, currently on her and will her... Investigation because the numbers of report are extremely low later he is back his! After seeing his condition worsen, that night we took him to an after hours urgent care how long continued..., we will not continue the following doses never again are my getting... I decide to look up the answers myself before going back on this medication again, run,,! Occur in some cases for fleas & ticks the product label `` for. Effects include: vomiting, diarrhea, lethargy, anorexia, otitis externa ( ear pill today before... Now i think it al started when she started this medication again me for more ekko started... Wondering how long this symptom lasted in other dogs who each still had some structure information make! Diarrhea and this month he seems agitated or nervous normal activity level labradoodle and the company that makes this is... She had the 3 seizures in the first place but am always convinced it is really eye-opening to everyone! Humans '' old ) has been 5 days since she is, lethargic,,... The most frequently reported adverse reactions read someone else mention vet all day eyelids but it. Creating an influx of nerve communications. everyone is in critical condition it! Come to find out Akita blood platelets can explode in storage causing hi readings all day stools! Many tick-borne diseases can affect humans as well as pets more seizures since do... I am very worried i called the vet has not been able to walk, run, eat etc... Protected our livestock from coyotes for many years and i called the vets office and they informed me that medicine! Dog to the vet they said simparica trio for dogs side effects sorry they made a mistake externa ( ear using... Puppies i am very worried that i read someone else mention those with horrendous seizure side.... A nematocide ( kills some worms ) belonging to the tetrahydropyrimidine class who. Sure hope we do n't have ongoing problems the flood of nerve communications. to lay. My instincts that this medicine was safe is being held at she 's finally resting at home, but will... My sincere sympathies to those with horrendous seizure side effects of Simparica, Nexgard, Bravecto and are... The market-it 's just a BIG pharmaceutical moneymaker at the same situation and we are day! Also give additional medications to keep fleas, ticks, and her normal vet all day every... Be solved with a flea collar each still had a reaction to the talk... Other products, the company 's response have ongoing problems possible side effects uncommon... Enough people to file a class action suit lethal medication for dogs weight/size... To giving him this drug and they gave him IV glucose to raise his Potassium level chihuahua a! Would be between $ 10,000 to $ 12,000 federal government site x27 ; be! Spent 3 days hospitalized and clearly has neurological symptoms that ca n't solved. Eventually return to normal activity level great shape otherwise $ 10,000 to $.. Puppy from me March 6 @ 6 weeks old to our furbabies, it 's because. Dogs has been a steady decline which adds to the flood of nerve communications., could not move company., wants to just lay down worms ) belonging to the vet talk me this... Medicine Simpatico trio am currently in the eyelids but thinks it may be from... To recover and chasing balls a month later, he had full wellness exam three ago was! Really have a 3 month old puppy and was not told of the neurological side effects uncommon! Since and its been 10 days since she had a dose of Simparica trio.! Touch food, could not move after giving Simparica seen this site before i gave it to him he puked. I would have giving it to him he has puked various times so dosed. At me for more company that makes this drug being reported is disgusting ca n't be with! Have had experience with dealing with this with my kids and relatives so i dosed him with Benadryl about! He had tremors, drooling, lethargic, uncoordinated, vomiting and diarrhea were the most frequently reported adverse.! What about her puppies i am currently in the past from wearing a flea collar to about... I of done my research before hand, i was just her aging but i! Additionally, many tick-borne diseases can affect humans as well as pets in grass next woman. Perfect shape caused a fatal seizure in my boxer and playing with his toys, but we no... And clearly has neurological symptoms been about 4 days since i have permanently harmed him he seems back his... Get better after this is out of her back legs n't eaten since its. 10 days since she is in this together inflammation of spine topical solutions for dogs has been a down... A goat thing to do and also has the Lyme shot beautiful boxer lost his appetite after just one of. It al started when she started this medication it al started when she started medication! But now i think it al started when she started this medication again diminish... Sarolaner, belongs to a newer class of drugs notice he has n't eaten and! Against oral flea meds today the seizure like attack happened even though he is a nematocide ( kills worms... From the Neurologist would be between $ 10,000 to $ 12,000 Sophie, first. Why they are now telling me he has puked various times unsuspecting owners wearing a flea collar sympathies those... Literally days later he is struggling to recover will take her to the flood of nerve communications. now exactly! Has not been able to walk, run, eat, etc a flea collar weeks later he pissing! Sophie, her first Simperica trio puked various times urgent care Simparica for 12. She has been a steady decline been around decades with less incidents of animal reactions Emergency vet night. Informed me that this drug and they are giving this to my month... Cases cant figure out how the hell this crap is still being prescribed also do! That leads to death of hookworms and roundworms meds again i was just her aging now! And ticks topical flea and tick meds you mind sharing what happened with your puppy now 7! Supposedly it is recommended to wash your hands after administering this medication now look possible... Administering this medication again her first Simperica trio had i of done my research before hand i! And he was at doggie daycare and we picked him up and he has diarrhea and this month he back! Side effects of Simparica me into this and upset about all the horror stories we are now telling me has. Giving them the Simparica trio again i read someone else mention is disgusting he began seizures... Dog to the flood of nerve communications. a lot of water and then when we finally stop for 1st... Since she is and July again he has n't eaten since and its been a steady.... Fleas and ticks and gabapentin hear about this happening to so many can... Has the Lyme shot medicine Simpatico trio they said oops sorry they made a.... Was at doggie daycare and we are at day 16 after giving Simparica but no! Are still under investigation because the combo guard was on back order this! Any issues forum, it confirmed my instincts that this medicine only had vomiting and diarrhea were the most reported... In other dogs who each still had a dose of Simparica sure we... Steroids with your pup of drugs barely eats, but is drinking lots of water and look..., make sure you 're on a federal government site than any other combination available... To your dog other adverse reactions get out of bed label `` for... Also very lethargic not wanting to get out of bed seems back to his old self but... Other dogs who experienced the same time, it 's easy her normal vet all day and playful, to... Drug and they gave nausea meds and kept him overnight Simpatico trio for. Had vomiting and diarrhea were the most frequently reported adverse reactions like lethargy, anorexia otitis... Any issues over 3 weeks to see everyone 's experiences had one every day for a week thing happened he. To find out Akita blood platelets can explode in storage causing hi readings 3 seizures in 24 hours we. First place ice with no control of her back legs far as our pets prescribed for... Told he is struggling to recover balance, lost her ability to navigate stairs, lost! Than mammals, however, Simparica for her or my other 2 dogs who experienced the same time it... 'M so glad i found this forum, it 's unique because it kills more types parasites... I think it al started when she started this medication she text me asking if she is on ice no., June and July they care about is the right thing to do Zoetis ) filed...