Youll likely take it once a day. If you develop liver problems, you may be more likely to experience side effects with Zetia. You can use the study as a second opinion to make health care decisions. They may have a preference for one version or the other. If you have symptoms of a severe allergic reaction, such as swelling or trouble breathing, call 911 or your local emergency number right away. Zetia isnt known to interact with grapefruit or any other foods. This included relief of muscle pain, muscle weakness, and cramps. High cholesterol occurs when you have more cholesterol in your blood than your body needs. If youre sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while youre using Zetia. Chylomicrons help your body, low-density lipoproteins (LDL), sometimes referred to as bad cholesterol, high-density lipoproteins (HDL), sometimes referred to as good cholesterol, triglycerides, which are a type of fat that are building blocks of cholesterol, Apo B (high levels of this protein are a sign of high cholesterol), non-HDL cholesterol (calculated by subtracting your HDL cholesterol level from your total cholesterol), were reduced by an average of 13% to 14% in people who used Zetia, ranged from not changing to being reduced by an average of 1% in people who used a placebo, were reduced by an average of 18% in people who used Zetia, increased by an average of 1% in people who used a placebo, decreased by an average of 13% to 14% in people who used Zetia alone, decreased by an average of 15% to 40% in people who used a statin alone, depending on the statin used, decreased by an average of 24% to 46% in people who used Zetia and a statin, depending on the statin used, ranged from decreasing by an average to 1% to increasing by an average of 4% in people who took a placebo, decreased by an average of 19% to 20% in people who used Zetia alone, decreased by an average of 20% to 54% in people who used a statin alone, depending on the statin used, decreased by an average of 34% to 61% in people who used Zetia and a statin, depending on the statin used. Instead, it belongs to a class of drugs called cholesterol absorption inhibitors. They may also check you for signs of muscle breakdown or kidney damage. It is not yet clear what are the causes of POTS disease. Here's how ApoB tests can help doctors evaluate cholesterol levels and, in some cases, provide a better understanding of a, At-home testing can provide clarity about your cholesterol levels and risk of heart disease. Before taking Zetia, talk with your doctor and pharmacist. Cholestyramine (Prevalite) is a drug used to treat high cholesterol. Other side effects not listed may also occur in some patients. However, animal studies dont always predict what will happen in humans. Your doctor will likely start you on the typical dosage approved to treat your condition. A clinical study looked at children ages 10 to 17 years old with heterozygous familial hypercholesterolemia (HeFH). For treatment of mixed hyperlipidemia, Zetia is indicated to reduce total cholesterol, LDL cholesterol, non-HDL cholesterol, and ApoB. Learn how we can help. If youre experiencing hair loss while using Zetia, talk with your doctor. If you have liver problems, your liver may not work properly to remove medications such as Zetia from your body. Your doctor might suggest one or more of these: fludrocortisone (helps the kidneys retain sodium) midodrine (causes the blood vessels to tighten) beta blockers (slow down the heart rate). Ask your doctor what other medications are better options for you. You may not have any symptoms of high cholesterol unless youve developed a type of heart disease called atherosclerosis (narrowing of the arteries). Another is trouble standing up, primarily because not enough blood returns to the heart upon standing, which causes a rapid increase in heart rate called tachycardia. Do not use more Zetia than your doctor recommends. These can be signs of rhabdomyolysis (muscle breakdown), which is a serious medical condition. Typical symptoms of POTS include: heart palpitations (feeling your heart beating or racing) dizziness or lightheadedness. Some common antihistamines that can cause ED are: Diphenhydramine (Benadryl) Dimenhydrinate (Dramamine) Hydroxyzine. It can develop suddenly or maybe over time. For more information, see the How Zetia works section below. . Zetia comes as a tablet that you swallow. Some people with POTS also may have one or more . The actual price youll pay depends on your insurance plan, your location, and the pharmacy you use. Zetia side effects. Zetia is sometimes used with medications in the statin drug class. Call your doctor right away if you have serious side effects. An increase in these liver enzymes while using a statin drug can cause severe liver disease. Its not known if Zetia is safe to take during pregnancy. A Mayo Clinic study published this month in Pacing and Electrophysiology (PACE), suggests that a class of medications more commonly prescribed for older adults is a strong first-line treatment for teenagers with a debilitating condition called postural orthostatic tachycardia syndrome, or POTS. Phil Fischer, M.D., medical director of Mayo Clinic's children's hospital and a POTS specialist, led . When this happens, more cholesterol can then be cleared from your blood by your liver. Zetias side effects are usually mild, especially if youre taking Zetia alone. muscle pain while taking ezetimibe with a statin. (A class of medications is a group of drugs that work in a similar way.) Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. For more information and to find out if youre eligible for support, call 800-727-5400 or visit the program website. If youd like to notify the FDA about a side effect youve had with Zetia, visit MedWatch. Tell them about all prescription, over-the-counter, and other drugs you take. If youre using Zetia while sexually active with a female who could become pregnant, talk with your doctor about your birth control needs. The underlying cause is not known, although it sometimes follows bedrest after injury or illness. If your doctor has prescribed Zetia and youre interested in using ezetimibe instead, talk with your doctor. (For more information on the specific conditions Zetia can treat, see the Zetia uses section.). Your doctor may stop your Zetia treatment if it isnt safe or effective for you. shortness of breath or troubled breathing. Examples of bile acid sequestrants include: Zetia inhibits the intestinal absorption of cholesterol and phytosterols, resulting in a decrease in the transport of intestinal cholesterol to the liver. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Homozygous familial hypercholesterolemia (HoFH), homozygous familial hypercholesterolemia (HoFH). To manage your symptoms, they may suggest an over-the-counter antihistamine you take by mouth, such as Benadryl (diphenhydramine). What is considered high cholesterol? Yes, there are a few. Ezetimibe can cause the breakdown of muscle tissue . Here are some natural statins that may help keep your cholesterol in a healthy. OI is a condition in which an excessively reduced volume of blood returns to the heart after an individual stands up from a lying down position. Zetia can be used to treat high cholesterol or homozygous sitosterolemia (a condition that causes high fat levels) in certain people. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Talk with your doctor if you have questions about using Zetia to lower your triglyceride levels. In studies, weight changes didnt occur in people who took the drug. Medications in the statin drug class work differently than cholesterol absorption inhibitors like Zetia. If youre concerned about weight gain while using Zetia, talk with your doctor. This may increase your risk of side effects. Zetia is indicated as an adjunct to a low-cholesterol diet for treatment of the following types of hyperlipidemia: For treatment of primary hyperlipidemia, Zetia is indicated to reduce total cholesterol, low-density lipoprotein (LDL) cholesterol, non-high-density lipoprotein (non-HDL) cholesterol, and apiloprotein B (ApoB). Zetia is approved to treat certain forms of high cholesterol in adults when used with a low-cholesterol diet. POTS is defined by its particular symptoms and an excessive increase in heart rate upon standing. LDL cholesterol was reduced by 15% more in children who took Zetia and simvastatin than in children who took simvastatin alone. Your child can take Zetia with or without food. Or they may recommend a product you apply to your skin, such as hydrocortisone cream. Zetia is approvedto treat certain forms of high cholesterol in children ages 10 years and older. Youll also need to check your insurance plan, as it may only cover one or the other. People who may be at higher risk of this side effect include those who: Tell your doctor if any of the above apply to you before starting Zetia treatment. Zinnia elegans 'Benary's Giant Golden Yellow'. Side effects may be more likely in older adults. Zetia is a prescription drug used to treat certain types of high cholesterol. This drug has not been studied in pregnant females.*. What foods should I avoid while taking Zetia. Its not known how many adults and children experienced muscle pain in clinical studies of other conditions treated with Zetia and statin drugs. The only FDA-approved dosage of Zetia for children is 10 mg once a day. Zetia may be used with statin drugs to treat the following conditions in adults: Statins are another class of medications used to lower cholesterol. weakness and fatigue (tiredness) headaches. Its not known if Zetia is safe to take during pregnancy. But keep in mind that Zetia is used to reduce cholesterol levels in your blood. A malfunctioning ANS is sometimes called 'dysautonomia'. Porphyrias have been associated with POTS symptoms (Stewart & Hensley, 1981). I am a stay at home mama to a sweet baby girl, and wife to an amazing h. The generic is considered to be as safe and effective as the original drug. They often originate at the base of the skull and spreading on the back of the head and neck. Or should I wait to see if I develop such side effects? However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Medications in this drug class prevent your liver from making new cholesterol. Less cholesterol entering your liver allows your liver to break down the cholesterol it already has stored. Talk with your doctor about the risks of taking Zetia with warfarin. This list contains examples of serious side effects that can occur with both Zetia and Crestor (when taken individually). MS: Can the Mediterranean diet help preserve cognitive health? These symptoms can be signs of an infection. Statins are commonly prescribed with Zetia to treat certain types of high cholesterol. Heres some detail on certain side effects this drug may or may not cause. Ezetimibe is used along with a low cholesterol/low fat diet and exercise to help lower cholesterol in the blood. 4. Theyll guide you with suggestions they may have to relieve these side effects. For instance, some interactions can interfere with how well a drug works. Zetia is a brand-name prescription drug. Zetia can cause the breakdown of muscle tissue, which can lead to kidney failure. Can diet help improve depression symptoms? As patients we need to be constantly wary because it is increasingly clear that the pharmas have abrogated their responsibility on our behalf. Zetia is also available in a generic form called ezetimibe. They can suggest ways to help relieve this side effect. Zetia (ezetimibe) is a prescription drug used to treat certain types of high cholesterol in adults and children. This disorder affects the autonomic nervous system, which controls involuntary body functions such as body temperature and heart rate. During your Zetia treatment, consider keeping notes on any side effects youre having. Ezetimibe may cause side effects. Statins lower cholesterol by preventing your liver from making new cholesterol. Before approving coverage for Zetia, your insurance company may require you to get prior authorization. Porphyria patients are often overly sensitive to sunlight. Learn about alternatives like new drugs, A new class of self-injectable medications are showing promise in treating high cholesterol. But if you have any symptoms that are ongoing or that bother you, talk with your doctor or pharmacist. POTS affects the body's ability to pump blood from the legs to the rest of the body while standing. Muscle problems are common side effects of statin drugs. Zetia hasnt been studied in certain types of dyslipidemia, including Frederickson types I, III, IV, and V. Zetia is taken orally with or without food. For example, in studies, some people had to stop taking the drug because their liver enzyme levels increased. Muscle-related problems are a possible side effect of Zetia when used with other medications. Effects of coenzyme Q10 on statin-induced myopathy: An updated meta-analysis of randomized controlled trials. Most patients will need at least 64 to 80 ounces (8 to 10 cups) of hydrating liquids throughout the day, such as water, broth, juice, or decaffeinated tea. The symptoms develop immediately and include dizziness and an intense headache. Zetia was prescribed to me after a severe reaction to Provochol with debilitating muscle pain. In fact, researchers have looked into using Zetia to treat hair loss due to a condition called alopecia areata. Zetia has a well-documented safety profile. Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. However, you should still check with your doctor or pharmacist before using any of these products while taking Zetia. Crestor contains the active drug rosuvastatin. POTS is a kind of dysautonomia or autonomic nervous disorder. It can develop suddenly or gradually over time. Increased liver enzymes can be a sign of liver damage. Serious side effects and their symptoms can include: * You may be more likely to experience this side effect if you take Zetia with a statin drug than if you take Zetia alone. Zetia may cause serious side effects including: muscle pain, muscle tenderness or weakness, fever, unusual tiredness, and. More common side effects in people taking Zetia* include: * In studies, these side effects were reported in people who took Zetia by itself. If you have side effects of Zetia that bother you, talk with your doctor or pharmacist. 1. Talk with your doctor before starting Zetia if youre pregnant or planning a pregnancy. High cholesterol may be caused by genetics, smoking, low amounts of physical activity, or eating too many high-cholesterol foods. Here we look at how Zetia and Lipitor are alike and different. It's Aimee Esther here! For this purpose, Zetia may be used alone or with fenofibrate. It wasnt reported during studies of the drug. And talk with your doctor if you have any questions about eating certain foods with Zetia. Depending on your age or other medical conditions you may have, you may be at higher risk of developing rhabdomyolysis while taking Zetia. Postural Orthostatic Tachycardia Syndrome (POTS) is a blood flow disorder that causes a sudden spike in heartbeat with no change in blood pressure when going from a horizontal or seated to a standing position. The insurance company will review the prior authorization request and decide if the drug will be covered. Recently, POTS has been diagnosed in some people who have had COVID-19. Using Zetia with medications in the fibrate drug class raises your risk of gallstones even more. Call 911 or your local emergency number if your symptoms feel life threatening or if you think youre having a medical emergency. Researchers analyzed data on nearly 300,000 patients from the Cedars-Sinai Health . For more information on these side effects, see Side effect details below. The absence of symptoms doesn't necessarily mean that the cause of POTS is gone as well. These drugs havent been directly compared in clinical studies. This can increase your risk of side effects from either medication. Examples of statin drugs include: Learn more about how grapefruit may interact with medications. Some side effects are more common than others. Zetia (ezetimibe) is prescribed to lower high cholesterol in adults and some children, along with a low cholesterol diet. Its not clear if CoQ10 prevents muscle-related side effects when Zetia is taken with a statin, but it might help. Covers lawsuits, malpractice, class actions, fraud, legislation, regulation, enforcement. These lists contain up to 10 of the most common mild side effects that can occur with Zetia, with Lipitor, or with both drugs (when taken individually). It can cause mild side effects and, less commonly, serious side effects. After first three days stopped it for two days. If you need financial support to pay for Zetia, or if you need help understanding your insurance coverage, help is available. If your muscle-related side effects dont go away or become severe, tell your doctor right away. Twelve weeks of treatment with Zetia and atorvastatin or simvastatin was compared with atorvastatin or simvastatin used alone. Other interactions can increase side effects or make them more severe. Talk with your doctor about your health history before you take Zetia. A few examples of statins include Lipitor (atorvastatin), Crestor (rosuvastatin), and Zocor (simvastatin). There arent any foods that have been specifically reported to interact with Zetia. Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. Medications in the fibrate drug class may increase the amount of cholesterol thats stored in your gallbladder. For more information on the possible side effects of Zetia, talk with your doctor or pharmacist. It isnt known how often this side effect occurred with Zetia in clinical studies. They can tell you whether the supplement may interact with any medications youre taking. For primary high cholesterol, Zetia is FDA-approved for use in adults and children* to decrease levels of: For this purpose, Zetia is used with a low-cholesterol diet. However, you shouldnt stop taking Zetia without first talking with your doctor. If you miss a dose of Zetia, you can take your missed dose as soon as you remember. Zetia may stay in your system for several days after you stop taking it. Your risk of developing serious side effects may increase if you take Zetia with other medications to treat high cholesterol, such as statin drugs. What are the serious side effects of Zetia? And Zetia hasnt been shown to affect blood sugar levels in clinical studies of people with diabetes and people without diabetes. This section doesnt contain all drugs that may interact with Zetia. Fenofibrate is a drug used to lower your triglyceride levels. The manufacturer of Zetia hasnt stated whether the tablets can be crushed, split, or chewed. This may be caused by genetics, smoking, not getting enough physical activity, or eating too many foods that are high in cholesterol. Your body uses cholesterol to make some vitamins, hormones, and fluids that help you digest food. Sharing this information can help you avoid potential interactions. Crestor is part of the statin drug class. Its primary metabolic pathway is via hepatic glucuronic conjunction. For more information about taking Zetia during pregnancy, see the Zetia and pregnancy section above. Symptoms of a swollen gallbladder may include: Tell your doctor if you experience gallstones while using Zetia with fenofibrate. This is a serious medical condition that, if left untreated, can lead to kidney damage. Diarrhea is a common side effect of Zetia. However, animal studies dont always predict what will happens in humans. The actual price youll pay for any of these drugs depends on your treatment plan, your insurance plan, your location, and the pharmacy you use. Both drugs are typically taken once each day. Taking Zetia with a statin drug may increase your risk of developing some mild or serious side effects. Talk with your doctor about any liver problems you may have and whether its safe for you to take Zetia. The brand name for this drug combination is Vytorin. The following information describes dosages that are commonly used or recommended. More research is needed to know for sure. Zetia can cause certain side effects, some of which are more common than others. About Postural orthostatic tachycardia syndrome. Clinical studies involved adults and children ages 10 years and older. Zetia is available in a strength of 10 milligrams (mg). Additionally, a change in weight is not a listed side . Eating large meals can worsen hypotension in some individuals with dysautonomia (Mathias, 2000). Total cholesterol consists of: High cholesterol occurs when you have more cholesterol in your blood than your body needs. If youre currently taking cyclosporine, talk with your doctor about whether its safe for you to take Zetia. POTS is commonly associated with low levels of fluid. Lipitor and Zetia belong to different drug classes. Zetias effect on cardiovascular morbidity and mortality isnt known. Cholesterol can also be found in foods such as eggs, cheese, and meat. However, you may still experience muscle problems if you use Zetia alone. This is especially helpful to do when you first start taking new drugs or using a combination of treatments. However, your cholesterol levels may increase if you stop taking the drug. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. * This is a partial list of mild side effects from Zetia. But, they can have side effects and might not be right for you. The heart beats faster to pump it up to the brain, but with little success. Symptoms of a severe allergic reaction can include: Call your doctor right away if you have a severe allergic reaction to Zetia. Read More. You can also ask your pharmacist for information on how to dispose of your medication. To reduce your symptoms in . In these groups, joint pain occurred in: The length of time that adults and children experienced joint pain while taking Zetia in these clinical studies isnt known. Symptoms of atherosclerosis may include confusion, fatigue (lack of energy), trouble breathing, or pain in your chest, arms, or legs. Other drugs are available that can treat your conditions. Symptoms can be mild or serious and can include: If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. Clinical studies for ezetimibe did not note any difference in weight in those that took the drug versus those that did not. I read that Zetia should be taken along with a diet low in cholesterol and saturated fat. Zetia contains the active drug ezetimibe. In addition to Goff's specific symptoms, POTS can be associated with neurocognitive impairments or "brain fog"; problems with body temperature regulation; gastroenterological symptoms like nausea, abdominal pain, diarrhea, or constipation; and dark red-blue discoloration of the legs. It also isnt known what percentage of adults and children experienced diarrhea in clinical studies of other conditions treated with Zetia. Zetia is primarily cleared from the body through fecal excretion. Zetia should be protected from moisture and shouldnt be stored in areas where it could get damp or wet, such as bathrooms. Liver problems. Rhabdomyolysis can also occur with statin drugs, and you may need to take Zetia with a statin. Learn more about some of the side effects that Zetia may cause. In addition, Zetia may be used with fenofibrate to treat mixed hyperlipidemia. Less commonly, taking Zetia may lead to serious side effects. They may be able to suggest ways to relieve this side effect. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Zetia is FDA-approved to treat mixed high cholesterol when used with fenofibrate. Leqvio is a prescription drug used to lower cholesterol. 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